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Pollen Allergy/ Molecular method and differential diagnosis at a glance!

2024-02-27 14:55:42Biznes SHKRUAR NGA REDAKSIA VOX
Pollen Allergy/ Molecular method and differential diagnosis at a glance!
Intermedica

Today we are advancing towards the future in diagnostics, taking the first step towards the new era of " Personalized Medicine ".

But what is Personalized Medicine?

It is precisely the adaptation of medical treatment to the individual characteristics of each patient. Wouldn't it be great if everyone had therapy personalized to their unique characteristics?

Modern medicines save millions of lives every year. However, not every medication may work for you as it does for other people. Age, lifestyle and health are all factors that influence the response to medications. Personalized medicine aims to individualize health care through special diagnostics and treatments for each patient.

All of us are unique. Our health is determined by our differences, which combine with the lifestyle and environment in which we live. Through clinical and diagnostic information, we can identify patterns that will help us determine our individual risk of developing a particular disease.

What is one of the scientific methods on which personalized medicine is based?

This is molecular technology, which is a special approach to allergy diagnosis, where each single allergen component is used to detect specific IgE antibodies with very high accuracy. This method can help in diagnosing allergic diseases which are becoming a concern for people.

According to the European Academy of Allergology and Clinical Immunology "Allergy is the most common chronic disease in Europe, 20% of allergy patients struggle every day with the fear of a possible asthma attack, anaphylactic shock or even death from an allergic reaction" (EAACI , 2016). As you can understand from the high numbers, carrying unidentified allergies directly affects the reduction of the standard of living, and the determination of an accurate therapy will lead to the prevention of negative effects.

What are the latest discoveries at the molecular level regarding pollen allergy, which is very widespread in our region?

The diagnosis of pollen allergies in the Mediterranean is characterized by many special challenges. The pollen release times of endemic plants are often parallel and can span the entire year, making it difficult to determine the relevant allergens. Additionally, many people are sensitive to certain pollen allergens.

Together with leading allergy specialists from the Mediterranean region, EUROIMMUN has developed a new multiparameter immunoblot based on precisely defined allergen molecules, which helps to detect and differentiate specific IgE class antibodies against inhalation allergens which are particularly important in the Mediterranean region.

The EUROLINE profile not only accurately identifies allergen-causing proteins, but also enables the differentiation of primary sensitizations and cross-reactions. As a result, the test facilitates the selection of an appropriate and personalized therapy for each patient.

The newest panel at the molecular level is the first multiparameter test for Mediterranean specific inhalant allergens (DPA-Dx Pollen Southern Europe) which provides us with 18 different molecules to determine in a personalized way which molecule of these elements the patient is allergic to sensitized.

What are the features and values ​​of Pollen molecular testing?

The panel is also being evaluated in independent studies. Recently, a publication of the research group from Charité Berlin showed the great analytical and clinical value of the profile. and Turkey, is currently evaluating the value of the test to support diagnosis in patients from large parts of southern Europe (www.ait2020.com)

Allergic respiratory diseases such as rhinitis, conjunctivitis and allergic asthma, in addition to the ever-increasing endemic prevalence, present a complexity and difficulty in etiological diagnosis due to a polysensitization of European populations.

The latest developments in molecular allergology require in these cases to determine the actual molecule that causes the allergic disease. This is complicated by the cross-reactivity of molecules that can be found in more than one specific pollen.

It seems that the traditional approach of allergists, clinical history and allergic skin tests, are insufficient today in polysensitized patients.

The implementation of the above methods is associated with only one name and this is Intermedica , the first laboratory that has offered and continues to offer molecular allergy diagnostics through the development of specific molecular allergy tests and the only one that currently includes this system, which will to increase the accuracy of the etiological diagnosis, of the molecule responsible for the allergy, so it will enable a more personalized treatment, with very high precision.


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