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Why are heart attacks less harmful at night? Here's the scientific explanation

2025-12-13 17:36:46Lifestyle SHKRUAR NGA REDAKSIA VOX
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New scientific studies are shedding light on why heart attacks that occur at night are often less severe than those in the early morning hours.

According to a study published in the "Journal of Experimental Medicine", this change is directly related to the activity of neutrophils, a type of white blood cell that plays a key role in the body's inflammatory response.

Neutrophils are most active during the day, due to circadian rhythms, the “biological clock” that regulates the body’s functions. During a heart attack, these cells react to repair the damage, but they often overdo it, causing severe inflammation that also damages healthy heart tissue. Researchers have found that almost half of the damage to the heart after an attack comes from this excessive inflammation.

Analysis of data from thousands of patients in Spain showed that heart attacks at night are associated with less damage, as neutrophils are less aggressive. The researchers then confirmed that in mice, as in humans, heart attacks in the early hours of the morning cause more extensive damage to the heart, precisely because of the increased activity of neutrophils at this time of day.

The scientists also tested an experimental molecule, ATI2341, that mimics a compound naturally produced by our bodies at night.

It targets a receptor on the surface of neutrophils and changes the cellular behavior of the white blood cells, putting them in a less active state.

This allows inflammation to be regulated without compromising the immune system. According to the study authors, blocking the circadian rhythms of neutrophils not only protected the hearts of the mice, but also improved their response to certain pathogens and reduced other harmful inflammatory processes.

The findings could pave the way for new therapies to protect internal organs from damage caused by excessive inflammation.


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