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Gray hair linked to body's defense mechanism against skin cancer

2025-11-10 21:10:08Lifestyle SHKRUAR NGA REDAKSIA VOX
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Gray hair may be more than just a sign of aging, as it may reflect the body's natural defense mechanism against cancer, according to a new study from the University of Tokyo.

A study published in Nature Cell Biology found that white hair comes from damaged stem cells in hair follicles that self-destruct to prevent the development of melanoma, a type of skin cancer.

Researchers led by Emi Nishimura and Yasuaki Mohri analyzed the stem cells responsible for producing melanocytes, the pigment cells that give hair and skin color.

They found that when these stem cells suffer serious DNA damage, they stop reproducing and self-destruct, preventing the damaged cells from dividing and spreading potentially cancerous mutations.

This process leads to gray or white hair.

The process is driven by the activation of key signaling molecules that trigger cell self-destruction.

However, under exposure to certain carcinogens such as ultraviolet B radiation, the same stem cells can continue to renew and multiply.

Researchers emphasize that while gray or white hair does not directly protect against cancer, the study offers new insights into how the body's defense systems balance between cell death and uncontrolled growth.

"These findings reveal that the same stem cell population can follow opposite fates (exhaustion or expansion) depending on the type of stress and microenvironmental cues. This redefines hair graying and melanoma not as unrelated events, but as different outcomes of stem cell responses to stress," said Nishimura.


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