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For the first time / Chinese scientists transplat pig lungs to humans

2025-08-25 20:33:29Kosova&Bota SHKRUAR NGA REDAKSIA VOX

For the first time / Chinese scientists transplat pig lungs to humans

A pig lung transplanted into a human for the first time in an experiment could open up new possibilities for organs needed for transplantation.

Chinese scientists reported that they had successfully inserted a genetically modified pig lung into a 39-year-old man with a dead brain who had suffered a brain hemorrhage.

In previous experiments, the hearts, liver, and kidneys of pigs have been transplanted into humans in a process known as xenotransplantation, but the lungs are more delicate, and there were fears that an animal organ would be rejected immediately.

The scientists said the pig's lung "maintained stability and functionality" for nine days in the man's body without major rejection or infection.

Writing in the journal Nature Medicine, the team from Guangzhou Medical University said the study showed the possibility of using pig lungs for transplantation.

"Future studies could refine the approach to lung xenotransplantation and move closer to clinical translation," they said.

The lung was genetically modified into six genes to remove substances that provoke an immune response in the body and introduce human genes to make the organ more compatible and improve transplant survival.

There were signs that the man's immune system had started attacking the organ, which caused some damage to the lungs, but this had started to improve towards the end of the experiment.

The big breakthrough was hailed as an important step forward in the use of animal organs for transplantation.

Beatriz Domínguez-Gil, director of the National Transplant Organization, said: "This study marks a milestone in translational medicine: for the first time, a genetically modified pig lung has been implanted in a human being with a dead brain.

"The significance of this discovery lies in the fact that, until now, xenotransplantation experiments in humans had been limited to the kidneys, heart and liver, but never to the lungs.

"This organ poses an even greater challenge because of its delicate physiological balance: it receives a very high blood flow and is constantly exposed to ambient air, making it particularly vulnerable," she said.


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