It is almost common that coffee does not make you drowsy although there are many who claim that they are not affected at all by a cup drunk in the evening.
"Caffeine modifies our biological clock by moving the hands," according to a group of American and British researchers who, in a study in Science Translational Medicine, described the molecular mechanism by which caffeine causes the biological rhythm to jump.
The scientists studied five volunteers over a period of more than a month and a half, subjecting them to different conditions: taking a dose of caffeine equal to two espresso coffees about three hours before bed, in dim light, or being exposed in the evening to a very strong light or combination of caffeine and strong light.
It is known that the advent of darkness produces a physiological response, through the hormone melatonin, which predisposes to sleep, while light has the effect of delaying it.
Caffeine has been shown to have the same effect as light: in practice, it jumps the pace of the biological clock by delaying the arrival of sleep by about 40 minutes, half of what is obtained by being exposed to light before bedtime.
One measure the researchers took by assessing melatonin levels in the study participants, which increases in the evening and decreases with the day in a cycle called the "circadian rhythm".